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Year : 2022  |  Volume : 6  |  Issue : 1  |  Page : 1

Integrating epigenetics in modern periodontology – Current concepts

Department of Dentistry, Autonomous Government State Medical College, Mirzapur, Uttar Pradesh, India

Date of Submission22-Nov-2021
Date of Acceptance24-Nov-2021
Date of Web Publication27-Jun-2022

Correspondence Address:
Nirma Yadav
Department of Dentistry, Autonomous Government State Medical College, Mirzapur, Uttar Pradesh
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/sidj.sidj_20_21

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How to cite this article:
Yadav N. Integrating epigenetics in modern periodontology – Current concepts. Saint Int Dent J 2022;6:1

How to cite this URL:
Yadav N. Integrating epigenetics in modern periodontology – Current concepts. Saint Int Dent J [serial online] 2022 [cited 2023 Jun 7];6:1. Available from: https://www.sidj.org/text.asp?2022/6/1/1/348381

Periodontitis is a chronic disease initiated by a representative, multifactorial, and bacterial challenge of microorganisms and inflammation, usually with genetic and epigenetic factors, in the host. It is well known in dentistry that oral bacteria in dental plaque induce periodontal disease and that the resulting progression is associated with several risk factors, such as genetics, lifestyle, and systemic disease. Epigenetic is derived from the Greek word first used by Conrad Waddington in 1942,[1] which means the study changes that do not entail a change in the sequence of DNA is a new scientific discipline in science that is revolutionizing biology. In simple words, its form can be understood as whenever two genetically identical individuals are nonidentical, which we can measure this phenomenon is known as epigenetic. The study of epigenetic characteristics is being extensively researched in medical education today, but the study of epigenetic characteristics in dental research is still in its infancy. Nevertheless, studies related to epigenetics in dentistry deserve attention because epigenetic mechanisms play an important role in the development of oral diseases and gene expression during oral disease processes.

Related published articles conclude that various epigenetic factors (inflammation-immune response, connective tissue-bone destruction)[2] may induce dental differences due to epigenetic modification in monozygotic twin pairs and that epigenetic modification (such as DNA methylation, histone modifications, and noncoding RNA) in the genome may affect various gene functions that can lead to various periodontal diseases, dental abnormalities during the tooth developmental stage, etc., Several studies have reported that inflammatory responses in infected pulp and periodontal tissue affect epigenetic modifications, leading to changes in gene expression.

Although comprehensive understanding, studies of periodontal disease focused on epigenetics in dentistry are still in the early stages. More evidence is needed to associate epigenetic alterations, periodontal diseases, and inflammatory dental pulp cells. Several trials are being conducted to identify as well as epi-drugs for the treatment and prevention of periodontal disease. Although these advances have not yet been realized in clinical settings, identifying biomarkers for diagnosis is warranted.

  References Top

Nomura Y, Morozumi T, Numabe Y, Ogata Y, Nakayama Y, Sugaya T, et al. Estimation of the periodontal inflamed surface area by simple oral examination. J Clin Med 2021;10:723.  Back to cited text no. 1
Cho YD, Kim WJ, Ryoo HM, Kim HG, Kim KH, Ku Y, et al. Current advances of epigenetics in periodontology from ENCODE project: A review and future perspectives. Clin Epigenetics 2021;13:92.  Back to cited text no. 2


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